An elderly immunocompromised man from the Kenai peninsula, Alaska, succumbed to Alaskapox, becoming one of seven reported cases in the state. Alaskapox, similar to smallpox and monkeypox, primarily affects small mammals and typically presents mild symptoms. However, the recent fatality highlights the potential severity, especially among immunocompromised individuals. Health officials urge heightened awareness among clinicians and the public, as the virus's origins and transmission remain under investigation.